PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling
نویسندگان
چکیده
Erica L. Jackson, Jose Manuel Garcia-Verdugo, Sara Gil-Perotin, Monica Roy, Alfredo Quinones-Hinojosa, Scott VandenBerg, and Arturo Alvarez-Buylla* Department of Neurological Surgery and Program in Developmental and Stem Cell Biology Departments of Neurological Surgery and Pathology University of California, San Francisco San Francisco, California 94143 University of Valencia Burjasot-4610 Valencia Spain
منابع مشابه
PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.
Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRalpha in the adult SVZ. Specifically labeled PDGFRalpha expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation ...
متن کاملPDGFRα expression distinguishes GFAP-expressing neural stem cells from PDGF-responsive neural precursors in the adult periventricular area.
Jackson et al. (2006) have reported that adult glial fibrillary acid protein (GFAP)-expressing neural stem cells (NSCs) also express platelet-derived growth factor (PDGF) receptor-α (PDGFRα), and that their stimulation by PDGF induced the formation of a glioma-like mass. Here, we reexamined the relationship between PDGFRα and GFAP expression within the three-dimensional organization of the adul...
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Neural stem cells (NSCs) as a heterogeneous multipotent and self- renewal population are found in different areas in the developing mammalian nervous system, as well as the sub-ventricular zone (SVZ) and the hippocampus of the adult brain. NSCs can give rise to neurons, astrocytes and oligodendrocytes. The aim of this study was to differentiate neural stem cells into noradrenergic–like cells in...
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عنوان ژورنال:
- Neuron
دوره 51 شماره
صفحات -
تاریخ انتشار 2006